Medical Research

Ways to Make CBD More Bioavailable and Soluble

Written by Petar Petrov

The main hindrance to CBD’s sweeping benefits is its low bioavailability, resulting in the need of much higher dosage, and respectively money, to achieve the desired effects.

Scientists have been working hard to overcome this inherent obstacle, and have come up with a couple of methods that may not be full-on solutions, but still dramatically improve CBD’s bioavailability. Those methods revolve around the principles of nanotechnology, which refer to making particles much, much smaller, and therefore more easily absorbable, and tailor them to the idiosyncrasies of CBD.


But first, we should mention a somewhat surprisingly simple approach to making CBD more effective, one that has nothing to do with fancy technologies – diet.

It seems something as simple, yet fundamental as healthy levels of saturated fats in our body are necessary to carry CBD to its designated destination. (1)

Water-Soluble CBD

However, diet is the more limited approach to making the most of CBD. The real problem is that CBD is hydrophobic, meaning it doesn’t dissolve in water, which is one of the main reasons behinds its low bioavailability, considering how much of the human body is made up of water.

So, making CBD more water-compatible, so to speak, basically equals making it more bioavailable and effective. Here is where we should emphasize the “water-compatible” part, as opposed to water-soluble – scientists haven’t found a way to make CBD completely dissolve into water, but rater to make it more compatible with it, and respectively bioavailable.

Scientist are currently taking three approaches to doing this.


Nanoemulsions work by breaking up molecules to tiny, nanoscopic droplets, usually between 10 to 100 nanometers big, and using surfactants to bring down the surface tension of the water, so that the droplets can mix into it better.


Microemulsions operate on the same principle as nanoemulsions, but are considered less effective – as far as emulsions are concerned, the smaller the particles, the better. Droplets, created through microemulsions, are usually between 100 and 5000 nanometers big.

Furthermore, microemulsions require the use of more surfactants, which can cause some side-effects with health implications, in addition to giving the product an unpleasant taste, usually bitter and/or soapy.


Liposomes are spherical structures, usually between 50 and 5000 nanometers big, made up of two hydrophilic layers and one hydrophobic bilayer, where CBD can be stored. It’s a very creative way to make CBD more water-friendly and deliver it into the body, kind of like sneaking it in under the disguise of the hydrophilic layers surrounding it.

However, as you might imagine, this process is quite complex and also requires lots of surfactants, in addition to working better with isolated cannabinoids as opposed to natural extracts.

Water still remains one of main obstacles to CBD’s bioavailability and optimal effects, however, scientists are finding ways to bypass it, and hopefully soon, they might even figure out how to overcome it altogether.



  1. Elmes MW et al, Fatty acid-binding proteins (FABPs) are intracellular carriers for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), J Biol Chem.2015 Apr 3;290(14):8711-21. Epub 2015 Feb 9. Journal Impact Factor = 4.010; Times Cited = 64

Image Credits:  Aaron Cadena/Medium

About the author

Petar Petrov

Petar is a freelance writer and copywriter, covering culture, art, society, and anything in-between that makes for a nice story. And as it so happens, cannabis is a great element to add to each of those conversations.