Cannabinoids act on various pathways in cells through cannabinoid receptors (CBs), which are not just present in humans, but in all mammals. Since cannabinoids have been shown to have valuable therapeutic use in humans, its rational that they would also be therapeutic for our pets. CBD works for both humans and our pets because we have the same endogenous cannabinoid system. There are, however, differences. Dogs, for example, are reported to have a higher number of CBs in the brain compared with humans. There are also differences in the structure of the CB2 receptors themselves between the two species, as well as in the metabolism of the cannabinoids I the body. Veterinary medical researchers should ensure that they become involved in parallel research on the potential value of cannabis for treatment of animal diseases. The DEA, however, has not given veterinarians the authority to possess, administer, dispense, or prescribe cannabis or cannabinoid products. Even in states like California where cannabis has been legalized, there is nothing in California law that would allow a veterinarian to prescribe, recommend, or approve marijuana for treating animals. Veterinarians are in violation of California law if they are incorporating cannabis into their practices. Some of the questions that will be addressed are, should provisions exist in state cannabis law that allow veterinarians to prescribe and recommend CBD? What are acceptable dosages for different animals and diseases? What is the best vehicle of CBD delivery?